is human recombinant Granulocyte Colony
Stimulating Factor (G-CSF), which is a
specific growth factor known to stimulate
production of neutrophils, a type of white
blood cells in the body that are essential
for fighting infections. It is active
during the normal course of hematopoiesis
and the hematopoietic stem cells get differentiated
into white blood cells in the presence
G-CSF is a protein having 175 amino acids,
and has no glycosylation. E.coli is used
for commercial manufacturing of recombinant
G-CSF as a biosimilar. ReliGrast®
can be therapeutically used for reversing
neutropenic conditions due to various
reasons. It can be used in chemotherapy
induced neutropenia, AIDS-associated neutropenia,
congenital, cyclic idiopathic neutropenia.
In the clinical trials conducted, ReliGrast®
has demonstrated efficacy in reducing
the duration of Neutropenia (compared
to 9 days) and recovery after ANC Nadir.
The reduction in the incidence of Febrile
Neutropenia, Grade 4 Neutropenia and Infection
is also significant.
is available in the strength of 300 mcg/0.5
ml, as a pre-filled syringe.