Medical Products

BortiRel® (Bortezomib) for Injection is an antineoplastic agent available for intravenous injection (IV) or subcutaneous use (SC). Bortezomib is a modified dipeptidyl boronic acid. Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins.

BortiRel® (bortezomib) for Injection is a proteasome inhibitor indicated for Multiple Myelomaas part of combination therapy for the treatment of patients with previously untreated multiple myeloma who are unsuitable for stem cell transplantation and for the treatment of progressive multiple myeloma in patients who have received at least one prior therapy and who have already undergone or are unsuitable for stem cell transplantation. BortiRel® is also indicated for Mantle Cell Lymphoma for the treatment of patients with mantle cell lymphoma who have relapsed or were refractory to at least one prior therapy.

It is available in 2 strengths viz.,3.5 mg wherein each single use vial (10 ml) contains 3.5 mg of Bortezomib I.P. as a sterile lyophilized powder and 2 mg wherein each single use vial contains 2 mg of Bortezomib I.P. as a sterile lyophilized powder.