Patents

Reliance Life Sciences is actively engaged in building a strong and diversified Intellectual Property portfolio in pharmaceuticals and biotechnology. So far, Reliance Life Sciences has filed over 360 patents at national and international levels and 126 patents have been granted covering the entire spectrum of its research and development activities

Reliance Life Sciences believes that the broad nature of its intellectual property provides several opportunities for product development, partnering and licensing.


Selected Publications of Reliance Life Sciences

Peer reviewed journals

Year 2014

  • A non-invasive method to evaluate the efficacy of human myoblast in botulinum-A toxin induced stress urinary incontinence model in rats. Urology Journal 10(4):1126-34 (2014)

Year 2013

  • Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential. European Journal of Medicinal Chemistry 67: 454-463 (DOI: 10.1016/j.ejmech.2013.06.016) (2013)
  • KRAS gene mutations in correlation with clinicopathological features of colorectal carcinomas in Indian patient cohort. Medical Oncology 30(3): 617 (DOI: 10.1007/s12032-013-0617-5) (2013)
  • Infant mouse brain passaged Dengue serotype 2 virus induces non-neurological disease with inflammatory spleen collapse in AG129 mice after splenic adaptation. Virus Research 173(2): 386 – 397 (2013)
  • Status of stem cell based clinical trials in the treatment for diabetes. Current Diabetes Review 9(6): 429-36 (2013)
Year 2012
  • Chromosomal aberrations in 2000 couples of Indian ethnicity with reproductive failure. Reproductive Biomedicine Online 25(2):209 – 218 (2012)
  • BRCA1/BRCA2 gene mutations/SNPs and BRCA1 haplotypes in early-onset breast cancer patients of Indian ethnicity. Medical Oncology 29(5): 3272 – 3281 (2012)
  • Genome-wide disease association study in chewing tobacco associated oral cancers. Oral Oncology 48(9): 831 – 835 (2012)
  • Improved n-butanol production by solvent tolerant Clostridium beijerinckii. Biomass and Bioenergy 37: 9-15 (DOI: 10.1016/j.biombioe.2011.12.046) (2012)
Year 2011
  • Process for biodiesel production from Cryptococcus curvatus. Bioresource Technology 102(22): 10436-10440 (2011)
  • Establishment of a Mesenchymal Stem Cell Bank. Stem Cells International Volume 2011, Article ID 905621, 8 pages http://dx.doi.org/10.4061/2011/905621 (2011)
  • Molecular approaches to improvement of Jatropha curcas Linn. as a sustainable energy crop. Plant Cell Reports 30(9): 1573 - 1591 (2011)
  • Aerobic Production of 1,3-Propanediol from Crude Glycerol from Jatropha Biodiesel Process. New Biotechnology 28(1): 19 – 23 (2011)
  • Molecular and cellular characterization of expanded and cryopreserved human limbal epithelial stem cells reveal unique immunological properties. Experimental Eye Research 92(1): 47 – 56 (2011)
  • Isolation of high quality RNA from various tissues of Jatropha curcas for downstream applications. Analytical Biochemistry 413(1): 63 – 65 (2011)
  • VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway. Angiogenesis 14(3): 371-380 (2011)
Year 2010
  • Immunologic properties of human dermal fibroblasts. Human Immunology 71(11): 1089 – 1098 (2010)
  • A novel method to prepare 5-Fluorouracil, an anti-cancer drug, loaded microspheres from Poly (N-vinyl caprolactum-co-acrylamide) and controlled release studies. Designed Monomers and Polymers 13(4): 325 – 336 (2010)
  • Immunosuppressive properties of human umbilical cord derived mesenchymal stem cells: Role of B7-H1 and IDO. Immunology & Cell Biology 88(8): 795 – 806 (2010)
  • Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent Pathway but partially by inhibition of NF- kappaB. Journal of Biological Chemistry 285(29): 22318 – 22327 (2010)
  • RNAi-mediated knockdown of AURKB and EGFR shows enhanced therapeutic efficacy in prostate tumor regression. Gene Therapy 17(3): 352 – 359 (2010)
  • Yeast functional screen to identify genetic determinants capable of conferring abiotic stress tolerance in Jatropha curcas. BMC Biotechnology 10:23 (doi:10.1186/1472-6750-10-23) (2010)
  • Novel synthetic gluco-disaccharide RSCL – 0409 – a lipopolysaccharide – induced Toll-like receptor-mediated signaling antagonist. The FEBS Journal 277(7): 1639 – 1652 (2010)
  • 9,10-Dihydro-2, 5-dimethoxyphenanthrene-1, 7-diol, from Eulophia ochreata inhibits inflammatory signaling mediated by Toll-like receptors. British Journal of Pharmacology 160(5): 1158 – 1170 (2010)

Year 2009
  • Prevalence and geographic distribution of hepatitis C virus genotypes in Indian patient cohort. Infection, Genetics and Evolution 9(4): 643 – 645 (2009)
  • Down regulation of inflammatory responses by novel caffeic acid ester derivative by inhibiting NF-kappa B. Journal of Clinical Immunology 29(1): 90 – 98 (2009)
  • Novel caffeic acid ester derivative induces apoptosis by expressing FasL and down regulating NF-KappaB: Potentiation of cell death mediated by chemotherapeutic agents. Journal of Cellular Physiology 218 (3) : 653 – 662 (2009)
  • A dihydrobenzofuram lignan induces cell death by modulating mitochondrial pathway and G2/M cell cycle and arrest. Journal of Medicinal chemistry 52(10): 3184 – 3190 (2009)
  • TP53 codon 72 polymorphism and cervical cancer: pooled analysis of individual data of 15834 women from 49 studies. The Lancet Oncology 10(8): 772 – 784 (2009)

Year 2008


  • Developments in polymeric devices for oral insulin delivery. Expert Opinion on Drug Delivery 5(4): 403-415 (2008)
  • Nano/micro technologies for delivering macromolecular therapeutics using 3 poly (D,L-lactide-co-glycolide) and its derivatives. Journal of Controlled Release 125(3): 193-209 (2008)
  • One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons. Biochemical and Biophysical Research Communication 373(2): 258 – 264 (2008)
  • Stem cells for the treatment of neurological disorders. CNS Neurological Disorders - Drug Targets 7(1): 98-109 (2008)
Year 2007
  • 8-Methyl-4-(3-diethylaminopropylamino) pyrimido [4',5';4,5] thieno (2,3-b) quinoline (MDPTQ), a quinoline derivate that causes ROS-mediated apoptosis in leukemia cell lines. Toxicology and Applied Pharmacology 222(1): 80 – 88 (2007)
  • A panel of tests to standardize the characterization of human embryonic stem cells. Regenerative Medicine 2(2): 179 – 192 (2007)
  • Similar pattern in cardiac differentiation of human embryonic stem cell lines, BG01V and ReliCell®hES1 under low serum concentration supplemented with bone morphogenic protein – 2. Differentiation 75(2): 112-122 (2007)
  • Generation and transplantation of dopaminergic neurons from embryonic stem cells. Current Stem Cell Research & Therapy 2(2): 139-147 (2007)
  • Heart Development: The Battle between Mesoderm and Endoderm. Stem Cells and Development 16(1): 3-5 (2007)
Year 2006
  • Enriched NCAM positive cells form functional dopaminergic neurons in the rat model of Parkinson's disease. Stem Cells and Development 15(4): 575-582 (2006)
  • Human embryonic stem cells have a unique epigenetic signature. Genome Research 16(9): 1075-1083 (2006)
  • Assessment of pluripotency and multi-lineage differentiation potential of NTERA-2 cells as a model for studying human embryonic stem cells. Cell Proliferation 39(6): 585-598 (2006)
  • Functional hepatocyte-like cells derived from mouse embryonic stem cells: A novel in vitro hepatotoxicity model for drug screening. Toxicology in Vitro 20(6): 1014-1022 (2006)
  • Characterization and in vitro differentiation potential of a new embryonic stem cell line, ReliCell® hES1. Differentiation 74(2-3):81-90 (2006)
  • Role of Smad- and Wnt-dependent pathway in embryonic cardiac development. Stem Cells and Development 15(1): 29-39 (2006)
Year 2005
  • Role of hepatocyte-like cells in differentiation of cardiomyocytes from mouse embryonic stem cells. Stem Cells and Development 14(2): 153-161 (2005)



Book Chapters

  • ‘Establishment of Mesenchymal Stem Cell Banks in India’ in Stem Cell Banking (Ed. Ilic D.) ISBN 978-1-4939-0584-3 Springer Science+Business Media NY, USA, Chapter11: pp. 111 – 122 (2014).
  • ‘GCP and Clinical Research standards in India’ in Good Clinical Practice: A Question & Answer Reference Guide (Ed. Hamrell M.) ISBN-10: 1882615980 Barnett International Publishers, USA, Chapter 19: pp. 626-640 (2013)
  • ‘Clinical trials with mesenchymal stem cells’ in. Fundamentals of Clinical trials and Research (Ed. Saini R.) ISBN-10: 8181913787 Paras Medical Publishers, Delhi, India, Chapter 20: pp. 186-211 (2012)
  • ‘Polymeric scaffolds for tissue engineering: an overview’ in Biotechnology Emerging Trends (Eds. Sayyed R. Z. and Patil A. S.) ISBN 9788172335878 Scientific Publisher, Jodhpur, India, pp 415-448 (2009)
  • ‘Establishment, Characterization and differentiation of human embryonic stem cells into three germ layers’ in Embryonic Stem Cell Research (Ed. Grier E.V.), ISBN 1-59454-849-8 Nova Science Publishers, NY, USA pp. 65-93 (2006)