Reliance Life Sciences is actively engaged
in building a strong and diversified Intellectual
Property portfolio in pharmaceuticals
and biotechnology. So far, Reliance Life
Sciences has filed over 360 patents at
national and international levels and 126 patents have been granted covering
the entire spectrum of its research and
development activities
Reliance Life Sciences believes that
the broad nature of its intellectual property
provides several opportunities for product
development, partnering and licensing.
Selected Publications
Year 2013
Contract manufacturing of biotech drugs in India - Crossing the regulatory hurdle. Pharma Times. Jan 45(01): 9-10.
Year 2012
Clinical trials with mesenchymal stem cells. In. Rajiv Saini (ed): Fundamentals of Clinical trials and Research (Ed 1). Paras Medical Publishers, Delhi. May, Chap 20, 186-211
Regulatory framework and challenges in developing biosimilar monoclonal antibodies and related biologics. Intern. J. Pharmaceutical Sci., Oct-Dec. 5(3): 1765-74.
Clicking to greater transparency and accountability. Perspectives in Clin. Res. Oct-Dec 3(4): 122-4.
Compensation in Clinical trials: Indian regulators raising the bar! IDMA Bulletin, XLIII(35), 15-21 Sep. 20-4.
Current regulations governing biosimilars. Pharma Times. May 44(05): 46-52.
Stage specific differentiation of human embryonic stem cells into hepatocyte like cells
using conditioned medium from a human hepatoma cell line.Stem Cell Studies. (2012) 16:11:22 | DOI: 10.4081/3683.
Radiolabeling of Umbilical cord derived mesenchymal stem cells (MSCs) for in vivo tracking. Mukerjee A, Tipnis S, Samuel G, Viswanathan C, Venkatesh M. Cancer Biotherapy and Radiopharmaceuticals.
Efficacy and Safety of Autologous Cultured Melanocytes delivered on Poly (DL-lactic acid) film: A Prospective Open-labeled, Randomized, Multicentre Study.Dermatologic Surgery.
Functional assessment of cord blood units using two different assays. International Journal of Haemaotology Oncology and Stem cell Research.
Chromosomal aberrations in 2000 couples of Indian ethnicity with reproductive failure. Reprod Biomed Online, 2012 Aug; 25(2):209-18. Epub 2012 Apr 30.
BRCA1/BRCA2 gene mutations/SNPs and BRCA1 haplotypes in early-onset breast cancer patients of Indian ethnicity, Med Oncol. 2012 Jul 3.
Genome-wide disease association study in chewing tobacco associated oral cancers, Oral Oncol. 2012 Sep; 48(9):831-5.
RET gene mutations and polymorphisms in medullary thyroid carcinomas in Indian patients, J Biosci. 2011 Sep; 36(4):603-11.
Improved production of gibberellic acid by Fusarium moniliforme. J. Microbiol. Res. 2: 51-55.
Improved n-butanol production by solvent tolerant Clostridium beijerinckii. Biomass and Bioenergy 37: 9-15
Year 2011
Process for biodiesel production from Cryptococcus curvatus. Bioresource Technology 102: 10436-10440.
Regulations and Guidelines governing Stem Cell based Products – Clinical Considerations. Perspectives in Clin. Res. Jul-Sep. 2(3): 94-9.
Establishment of a Mesenchymal Stem Cell Bank.Stem Cells International; Article ID 905621.
Directed therapeutic angiogenesis by mesenchymal stem cells from umbilical cord matrix in preclinical model of ischemic limb disease. Stem Cell Studies; 1:e16; 97-104.
Efficacy of single dose (once weekly administration) of recombinant human erythropoietin "Relipoietin TM" in patients of CKD (chronic kidney disease) with anemia, Indian medical Gazette 2011, 145(7), 278-8.
Evolving Regulatory Paraphernalia , The Big Pharma April 2011, vol 1 issue 1 page 56 -59
Molecular approaches to improvement of Jatropha curcas Linn. as a sustainable energy crop- Plant Cell Reports. (2011)
Registration of Medical devices. PICR (2011)
Jatropha curcas: A Review on Biotechnological Status and Challenges- Plant Biotech Reports. (2011)
Aerobic Production of 1,3-Propanediol from Crude Glycerol from Jatropha Biodiesel Process - New Biotechnology (2011)
Molecular and Cellular Characterization of Expanded and Cryopreserved Human Limbal Epithelial Stem Cells Reveal Unique Immunological Properties-Experimental Eye Research Journal (2011)
Histological evidence of morphogenesis from various explants of Jatropha curcas L Trees - Structure and Function journal (2011)
Isolation of high quality RNA from various tissues of Jatropha curcas for downstream applications Anal- Biochem (2011)
Formulation and In vitro Evaluation of Transdermal Delivery of Zidovudine- An Anti-HIV Drug- Journal of Applied Polymer Science (2011)
Year 2010
Registration of Medical Devices. Perspectives in Clin. Res. Jul-Sep. 1(3): 90-3
Identification and Evaluation of Potential Systemic Toxicity of Recombinant Human Interleukin-2 in Wistar Rats based on Therapeutic Dosing Regimen Journal of Indian society of toxicology (2010)
Efficient plant regeneration from immature embryo cultures of Jatropha curcas, a biodiesel plant- Plant Biotechnology Reports (2010)
Immunological properties of human dermal fibroblasts-Human Immunology (2010)
Novel Thermo-Responsive Semi-Interpenetrating Network Microspheres of Gellan Gum-Poly (N-isopropylacrylamide) for Controlled Release of Atenolol-J. Appl. Polymer Sci (2010)
A Method to Prepare Microspheres from Novel Poly (N-vinyl caprolactum-co-acrylamide) Polymeric Matrices for Controlled Release of 5-Fluorouracil, an Anti-cancer Drug- Journal of Biomaterials-designed monomers & polymers (2010)
Micropropagation methods for Global Seed Vault crops- Current Science, (2010)
Immunosuppressive Properties of Human Umbilical Cord Derived Mesenchymal Stem Cells: Role of B7-H1 and IDO-Immunology and cell biology (2010)
Use of human embryonic stem (hES) cell based model for developmental toxicity-Cell biology international (2010)
Novel Derivative of Benzofuran Induces Cell Death Mostly by
G2/M Cell Cycle Arrest through p53-dependent Pathway but Partially by Inhibition of NF-_B-The journal of biological chemistry (2010)
Therapeutic potential of RNA interference-directed knockdown of Aurora B in human cancer cell lines-Gene therapy, (2010)
Yeast functional screen to identify genetic determinants capable of conferring abiotic stress tolerance in Jatropha curcas L- BMC Biotechnology (2010)
A novel dermal tissue construct: development and in vitro characterization. Biotechnol Prog (2010)
Comparison of proliferative and multilineage differentiation potentials of cord matrix cord blood and bone marrow derived mesenchymal stem cells- Asian J Transf Sci (2010)
Umbilical cord matrix derived mesenchymal stem cells can change the cord transplant scenario- Intl J Stem Cells (2010)
Transplantation of autologous bone marrow derived mesenchymal stem cells trans-epicardially in patients undergoing coronary bypass surgery- Indian Heart Journal (2010)
Derivation, expansion and characterization of clinical grade mesenchymal stem cells from umbilical cord matrix using cord blood serum- Intl J Stem Cells (2010)
Novel thermo-responsive semi-interpenetrating network microspheres of gellan gum-poly(N-isopropylacrylamide) for controlled release of atenolol- J. Appl. Pol. Sci. (2010)
A Novel synthetic gluco-disaccharide [4-O-Chloroacetyl-2,3-di-O-acetyl-6-O-levulinoyl--D-glucopyranosyl]-(1-3)-1-O-(p-methoxyphenyl)-2-deoxy-2-N-trichloroacetyl-4,6-O-benzylidene--D-glucopyranoside (RSCL-0409), a LPS induced Toll-Like Receptor mediated signaling antagonist FEBS J 2010
Clinical grade mesenchymal stem cells transdifferentiated under xenofree conditions alleviates motor deficiencies in a rat model of Parkinson's disease- Cell Biology International (2009)
Formulation and In vitro Evaluation of Transdermal Delivery of Zidovudine- An Anti-HIV Drug- Journal of Applied Polymer Science, (2009)
Prevalence and Geographic Distribution of Hepatitis C Virus Genotypes in Indian Patient Cohort Infection, Genetics and Evolution,Available online 11 April 2009
Down regulation of Inflammatory Responses by Novel Caffeic Acid Ester Derivative by Inhibiting NF-kappa B- Journal of Clinical Immunology 2009, (29), pp. 90 – 98
Novel caffeic acid ester derivative induces apoptosis by expressing fasl and down regulating NF-Kappa B: Potentiation of cell death mediated by chemotherapeutic agents-Journal of cellular physiology. 2009 Mar; 218 (3) :653-62.
A dihydrobenzofuram lignan induces cell death by modulating mitochondrial pathway and G2/M cell cycle and arrest-Journal of Medicinal chemistry April 2009
Polymeric scaffolds for tissue engineering: an overview, Biotechnology Emerging Trends, edited by R Z Sayyed and A S Patil- Scientific publisher, Jodhpur, India, pp 415-448 (2009).
TP53 codon 72 polymorphism and cervical cancer: pooled analyisis of individual data of 15834 women from 49 studies-The Lancet Oncology (2009)
Genotype Distribution in Cervical Cancer in India: Results from a Multi-Center Study.
Asian Pac J Cancer Prev (2009)
Occurrence of vivipary in Jatropha curcas-Current Science (2009)
India's first public cord blood repository — looking back and moving forward- Indian Journal of Hematology & Blood Transfusion, 2009, Volume 25, 111-117
Year 2008
High-frequency plant regeneration from leaf-disc cultures of Jatropha curcas L.: an important biodiesel plant-Plant Biotechnol. Rep. 2, 7-11 (2008)
Lactic acid production by Lactobacillus delbrueckii in a dual reactor system using packed bed biofilm reactor-Letters in Applied Microbiology Volume 46 Issue 6, Pages 661 - 666
Developments in polymeric devices for oral insulin delivery-Expert opinion on Drug
Delivery Expert Opinion on Drug Delivery, April 2008, Vol. 5, No. 4, Pages 403-415. (2008)
Nano/micro technologies for delivering macromolecular therapeutics using 3 poly (D,L-lactide-co-glycolide) and its derivatives-Journal of Controlled Release 125: 193-209
An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. Zooepidemicus-Biotechnology Letters 30: 493-496
Three-dimensional organization of
dermal fibroblasts by macromass culture.
Biotechnol Appl Biochem 49(Pt 1 ):65-72
Microencapsulation of Doxycycline into Poly(lactide-co-glycolide) by Spray Drying Technique: Effect of Polymer Molecular Weight on Process Parameters- J. Appl. Polymer Sci. Volume 108 Issue 6, Pages 4038 - 4046 (2008)
Cultured Melanocytes: From skin biopsy to transplantation-Cell Transplantation 2008; 17(3):351-60. (2008)
One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons- Biochem Biophys Res Commun. 373(2):258-64(2008)
Stem cells for the treatment of neurological disorders- CNS Neurol Disord Drug Targets. 2008; 7(1):98-109.
Assessment of drug induced developmental toxicity using human embryonic stem cells - Cell Biology International Volume 32, Issue 11, November 2008, Pages 1412- 1424
Year 2007
Cell cycle regulation in maintaining immortality of embryonic stem cells- J Stem Cells, 2007; 2(3): 159-66.
8-Methyl-4-(3-diethylaminopropylamino) pyrimido [4',5';4,5] thieno (2,3-b) quinoline (MDPTQ), a quinoline derivate that causes ROS-mediated apoptosis in leukemia cell lines-
Toxicology and Applied Pharmacology (2007)
A panel of tests to standardize the characterization of human embryonic stem cells- March 2007, Vol. 2, No. 2, Pages 179-192 (doi:10.2217/17460751.2.2.179)
Modulating fertility outcome in assisted reproduction technologies by the use of dydrogesterone- Gynaecological Endocrinology 23(S1): 68-72 (2007)
Solvent Detergent Treated Plasma: Safer Tool in the Hands of Transfusionists - Indian Journal of Hematology and Blood Transfusion Vol 33 /1 – 2, Pgs 32 - 35 (2007)
Human Umbilical Cord Blood Serum can replace foetal bovine serum in the culture of mesenchymal stem cells- Cell Biology International, 31293-298 (2007)
Similar pattern in cardiac differentiation of human embryonic stem cell lines, BG01V and ReliCell™ hES1 under low serum concentration supplemented with BMP-2- Differentiation. 75(2):112-122, February 2007
Generation and transplantation of dopaminergic neurons from Embryonic stem cells- Current Stem Cell Research & Therapy (2007), 2(2), 139-147
Heart Development : The Battle between Mesoderm and Endoderm-Stem Cells and Development (2007) 16 (1), 3-6
Year 2006
Enriched NCAM positive cells form functional dopaminergic neurons in the rat model of Parkinson's disease-Stem Cells Dev Stem Cells and Development. August 2006, 15(4): 575-582 (2006)
Human embryonic stem cells have a unique epigenetic signature-Genome Research Genome Res. Sep; 16(9):1075-83. 2006
Assessment of pluripotency and multi-lineage differentiation potential of NTERA-2 cells as a model for studying human embryonic stem cells-Cell Prolif. Dec; 39(6):585-98 (2006)
Functional hepatocyte-like cells derived from mouse embryonic stem cells. A novel in vitro hepatotoxicity model for drug screening- Toxicity in vitro (20): 1014-1022 (2006)
Characterisation and in vitro differentiation potential of a new embryonic stem cell line, ReliCell hES1-Differentiation 74(2-3):81-90 (2006)
A Smad- and Wnt-dependent pathway in embryonic cardiac development- Stem Cells Dev 15(1): 129-139 (2006).
Establishment, Characterization and differentiation of human embryonic stem cells into three germ layers-Chapter in book Human embryonic stem cells, Nova publications pp. 65-93 (2006)
Year 2005
Role of hepatocyte-like cells in differentiation of cardiomyocytes from mouse embryonic stem cells- Stem Cells Dev 14(2): 153-161 (2005)
The trans-differentiation potential of limbal fibroblast cells- Dev Brain Res 160(2): 239-251 (2005)
